Research

Representative Publications:

  1.  Zhao X, Kwan JYY, Yip K, Liu PP, Liu FF. Targeting metabolic dysregulation for fibrosis therapy. Nature Reviews Drug Discovery. Sep 23, 2019.
  2. Zhao X, Psarianos P, Ghoraie LS, Yip KW, Goldstein D, Gilbert R, Witterick I, Pang H, Hussain A, Lee JH, Williams J, Bratman SV, Ailles L, Haibe-Kains B, Liu FF. Metabolic regulation of dermal fibroblasts contributes to skin extracellular matrix homeostasis and fibrosis. Nature Metabolism. Jan 1(1):147-157, 2019.
  3. Inoue M, Nakashima R, Enomoto M, Koike Y, Zhao X, Yip K, Huang SH, Waldron JN, Ikura M, Liu FF, Bratman SV. Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis. Nature Communications. Nov 9(1):5116, 2018.
  4. Su B, Xu T, Bruce JP, Yip KW, Zhang N, Huang Z, Zhang G, Liu FF, Liang J, Yang H, Claret FX. hsa‑miR‑24 suppresses metastasis in nasopharyngeal carcinoma by regulating the c‑Myc/epithelial‑mesenchymal transition axis. Oncology Reports. Nov 40(5):2536-2546, 2018.
  5. Kwan JYY, Su J, Huang SH, Ghoraie LS, Xu W, Chan B, Yip KW, Giuliani M, Bayley A, Kim J, Hope AJ, Ringash J, Cho J, McNiven A, Hansen A, Goldstein D, de Almeida JR, Aerts HJ, Waldron JN, Haibe-Kains B, O’Sullivan B, Bratman SV, Liu FF. Radiomic Biomarkers to Refine Risk Models for Distant Metastasis in HPV-related Oropharyngeal Carcinoma. International Journal of Radiation Oncology, Biology, Physics. Nov 102(4):1107-1116, 2018.
  6. Bissey PA, Law JH, Bruce JP, Shi W, Renoult A, Chua MLK, Yip KW*, Liu FF. Dysregulation of the MiR-449b target TGFBI alters the TGFβ pathway to induce cisplatin resistance in nasopharyngeal carcinoma. Oncogenesis. May 7(5):40, 2018.
  7. Kinoshita T, Yip KW, Spence T, Liu FF. MicroRNAs in extracellular vesicles: potential cancer biomarkers. Journal of Human Genetics. Jan 62(1):67-74, 2017.
  8. Kwan JY, Psarianos P, Bruce JP, Yip KW*, Liu FF. The complexity of microRNAs in human cancer. Journal of Radiation Research. Aug 57:Suppl 1:i106-i111, 2016.
  9. Spence T, Bruce J, Yip KW*, Liu FF. HPV Associated Head and Neck Cancer. Cancers (Basel). Aug 8(8), 2016.
  10. Bratman SV, Bruce JP, O’Sullivan B, Pugh TJ, Xu W, Yip KW, Liu FF. Human Papillomavirus Genotype Association With Survival in Head and Neck Squamous Cell Carcinoma. JAMA Oncology. Jun 2(6):823-826, 2016.
  11. Shi W, Bruce J, Lee M, Yue S, Rowe M, Pintilie M, Kogo R, Bissey PA, Fyles A, Yip KW*, Liu FF. MiR-449a promotes breast cancer progression by targeting CRIP2. Oncotarget. Apr 7(14):18906-18918, 2016.
  12. Spence T, Bruce J, Yip KW*, Liu FF. MicroRNAs in nasopharyngeal carcinoma. Chin Clin Oncol. Apr 5(2):17, 2016.
  13. Bruce JP, Yip KW, Bratman SV, Ito E, Liu FF. Nasopharyngeal Cancer: Molecular Landscape. Journal of Clinical Oncology. Oct 33(29):3346-55, 2015.
  14. Kogo R, How C, Chaudary N, Bruce J, Shi W, Hill RP, Zahedi P, Yip KW*, Liu FF. The microRNA-218-Survivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer. Oncotarget. Jan 6(2):1090-100, 2015.
  15. Saurabh K, Scherzer MT, Song A, Yip KW, Reed JC, Li C, Beverly LJ. Dissecting the in vivo leukemogenic potency of BCLxl. Journal of Leukemia (Los Angel). Sep 2(5):158, 2014.
  16. Williams JP, Kim I, Ito E, Shi W, Yue S, Siu LL, Waldron J, O’Sullivan B, Yip KW*, Liu FF. Pre-clinical characterization of Dacomitinib (PF-00299804), an irreversible pan-ErbB inhibitor, combined with ionizing radiation for head and neck squamous cell carcinoma. PLoS One. May 9(5):e98557, 2014.
  17. Yip KW, Zhang Z, Sakemura-Nakatsugawa N, Huang JW, Vu NM, Chiang YK, Lin CL, Kwan JY, Yue S, Jitkova Y, To T, Zahedi P, Pai EF, Schimmer AD, Lovell JF, Sessler JL, Liu FF. A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase. PLoS One. Feb 9(2):e89889, 2014
  18. Ito E, Yip KW, Liu FF. Uroporphyrinogen decarboxylase: optimizing radiotherapy for head and neck cancer. Future Oncology. May 7(5):595-597, 2011.
  19. Yip KW, Cuddy M, Pinilla C, Giulanotti M, Heynen-Genel S, Matsuzawa S, Reed JC. A High Content Screening (HCS) Assay for the identification of chemical inducers of PML oncogenic domains (PODs). Journal of Biomolecular Screening. February 16(2):251-258, 2011.
  20. Garrison JB, Correa RG, Gerlic M, Yip KW, Krieg A, Tamble CM, Shi R, Welsh K, Duggineni S, Huang Z, Ren K, Du C, Reed JC. ARTS and Siah collaborate in a pathway for XIAP degradation. Molecular Cell. January 41(1):107-116, 2011.
  21. Yip KW, Kim I, Garrison J, Cortez A, Cheung N, Aza-Blanc P, Konopleva M, Andreeff M, Reed JC. Development and validation of an RNAi screen for ABT-737 sensitizers. International Journal of High Throughput Screening. September (1):163-170, 2010.
  22. Hayashi H, Cuddy M, Shu VC, Yip KW, Madiraju C, Diaz P, Matsuyama T, Kaibara M, Taniyama K, Vasile S, Sergienko E, Reed JC. Versatile assays for high throughput screening for activators or inhibitors of intracellular proteases and their cellular regulators. PLoS One. October 4(10):e7655, 2009.
  23. Ito E, Yip KW, Katz D, Fonseca SB, Hedley DW, Chow S, Xu GW, Wood TE, Bastianutto C, Schimmer AD, Kelley SO, Liu FF. Potential use of cetrimonium bromide as an apoptosis-promoting anti-cancer agent for head and neck cancer. Molecular Pharmacology. November 76(5):969-983, 2009.
  24. Yip KW, Reed JC. Bcl-2 family proteins and cancer. Oncogene. October 27(50):6398-6406, 2008.
  25. Yip KW, Godoi PH, Zhai D, Garcia X, Cellitti JF, Cuddy M, Gerlic M, Chen Y, Satterthwait A, Vasile S, Sergienko E, Reed JC. A TR3/Nur77 peptide-based high-throughput fluorescence polarization screen for small molecule Bcl-B inhibitors. Journal of Biomolecular Screening. August 13(7):665-673, 2008.
  26. Mocanu JD**, Yip KW**, Skliarenko J, Shi W, Busson P, Lo KW, Bastianutto C, Liu FF. Imaging and modulating antisense microdistribution in solid human xenograft tumor models. Clinical Cancer Research. October 13(19):5935-5941, 2007. [**These authors contributed equally to this work]
  27. Mocanu JD, Yip KW, Alajez NM, Shi W, Li JH, Lunt SJ, Moriyama EH, Wilson BC, Milosevic M, Lo KW, van Rooijen N, Busson P, Bastianutto C, Liu FF. Imaging the modulation of adenoviral kinetics and biodistribution for cancer gene therapy.Molecular Therapy. May 15(5):921-929, 2007.
  28. Yip KW, Shi W, Pintilie M, Martin JD, Mocanu JD, Wong D, MacMillan C, Gullane P, O’Sullivan B, Bastianutto C, Liu FF. Prognostic significance of the Epstein-Barr virus, p53, bcl-2, and survivin in nasopharyngeal cancer. Clinical Cancer Research. October 12(19):5726-5732, 2006.
  29. Yip KW, Mao X, Au PY, Hedley DW, Chow S, Dalili S, Mocanu JD, Bastianutto C, Schimmer A, Liu FF. Benzethonium chloride: a novel anticancer agent identified utilizing a cell-based small molecule screen. Clinical Cancer Research. September 12(18):5557-5569, 2006.
  30. Yip KW, Ito E, Mao X, Au PY, Hedley DW, Mocanu JD, Bastianutto C, Schimmer A, Liu FF. Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Molecular Cancer Therapeutics. September 5(9):2234-2240, 2006.
  31. Yip KW, Mocanu JD, Au PY, Sleep GT, Huang D, Busson P, Yeh WC, Gilbert R, O’Sullivan B, Gullane P, Bastianutto C, Liu FF. Combination Bcl-2 antisense and radiation therapy for nasopharyngeal cancer. Clinical Cancer Research. November 11(22):8131-8144, 2005.
  32. Mocanu JD, Moriyama EH, Chia MC, Li JH, Yip KW, Huang DP, Bastianutto C, Wilson BC, Liu FF. Combined in vivo bioluminescence and fluorescence imaging for cancer gene therapy. Molecular Imaging. October 3(4):352-355, 2004.
  33. Yip KW, Li A, Li JH, Shi W, Chia MC, Al Rashid S, Mocanu JD, Louie AV, Sanchez O, Huang D, Busson P, Yeh WC, Gilbert R, O’Sullivan B, Gullane P, Liu FF. Potential utility of BimS as a novel apoptotic therapeutic molecule. Molecular Therapy. September 10(3):533-544, 2004

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